Batch and continuous flow preparation of Hantzsch 1,4-dihydropyridines under microwave heating and simultaneous real-time monitoring by Raman spectroscopy. An exploratory study.
نویسندگان
چکیده
Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem's microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times.
منابع مشابه
Silica Boron Sulfonic Acid as Heterogeneous and Highly Efficient Solid Acid Catalyst For the Preparation of Hantzsch 1,4-dihydropyridines Under Solvent-Free
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ورودعنوان ژورنال:
- Molecules
دوره 19 7 شماره
صفحات -
تاریخ انتشار 2014